Anti-POGLUT1 Antibody

Catalog No : IGX-47630
262.00€
188.00€

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Description Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PMID:21081508, PMID:21490058, PMID:21949356, PMID:27807076, PMID:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PMID:21081508, PMID:21490058, PMID:21949356, PMID:27807076, PMID:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PMID:27807076). Notch glucosylation does not affect Notch ligand binding (PMID:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane .
Other names Protein O-glucosyltransferase 1, EC 2.4.1.-, CAP10-like 46 kDa protein, hCLP46, KTEL motif-containing protein 1, Myelodysplastic syndromes relative protein, O-glucosyltransferase Rumi homolog, hRumi, Protein O-xylosyltransferase POGLUT1, EC 2.4.2.26, POGLUT1, C3orf9 CLP46 KTELC1 MDSRP
Cellular localization Endoplasmic Reticulum Lumen
Research area Developmental Biology
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID Q8NBL1
Product name Anti-POGLUT1 Antibody
Catalog No IGX-47630
Supplier’s Catalog No IGX-47630
Supplier ImuGeX
Host species Rabbit
Species reactivity Human
Applications ELISA, WB, IHC
Recommended dilutions WB: 1:1000-1:5000, IHC: 1:200-1:500
Molecular weight Predicted band size: 47 KDa. Observed band size: 47 KDa.
Conjugate Unconjugated
Immunogen Recombinant Human Protein O-glucosyltransferase 1 protein (132-392AA)
Specificity POGLUT1 antibody detects endogenous level of POGLUT1 protein
Storage Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration Concentration can vary between different batches.
Storage buffer Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol.
Formulation Liquid
Purification This antibody is immunogen affinity purified.
Handling This product contains Proclin as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions (provided antibody remains sterile).