Anti-DCLRE1B Antibody
Catalog No : IGX-61464
237.00€
175.00€
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| Description | 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. | ||
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| Other names | DCLRE1B, SNM1B, 5' exonuclease Apollo, DNA cross-link repair 1B protein, SNM1 homolog B, SNMIB, hSNM1B | ||
| Cellular localization | Centrosome, Nucleus, Telomere | ||
| Research area | Developmental Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9H816 | ||
| Product name | Anti-DCLRE1B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-61464 | ||
| Supplier’s Catalog No | IGX-61464 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | WB, ELISA | ||
| Recommended dilutions | WB:1:500-1:2000.ELISA:1:40000 | ||
| Molecular weight | |||
| Conjugate | Unconjugated | ||
| Immunogen | Synthetic peptide derived from the C-terminal region of human SNM1B. | ||
| Specificity | This antibody detects total endogenous levels of DCLRE1B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||
| Formulation | Liquid | ||
| Purification | Antigen Affinity Purified | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile).. | ||
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