Transferrin, Human, HOLO, 97+% (Iron-saturated Siderophilin, TRF)
Catalog No : USB-T8199-12B
575.88€
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| Product name | Transferrin, Human, HOLO, 97+% (Iron-saturated Siderophilin, TRF) | ||
|---|---|---|---|
| Catalog No | USB-T8199-12B | ||
| Supplier’s Catalog No | T8199-12B | ||
| Supplier | US Biologicals | ||
| Source antigen | Human plasma | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 77 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~ 97% as determined by cellulose acetate | ||
| Form | Supplied as a pink lyophilized powder. No stabilizing proteins added. Reconstitute lyophilized Transferrin in sterile ddH2O ≥100ug/ml, which can then be further diluted to other aqueous solutions. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~ 97% as determined by cellulose acetate | ||
| Description | Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of ~79.5kD and a serum concentration range of 1800–2700mg/L. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in hemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. Human Transferrin is a glycoprotein with homologous N-terminal and C-terminal iron binding domains. Transferrin(TF) is related to other iron binding proteins including lactoferrin. When human transferrin loaded with iron encounters a transferrin receptor on the surface of a cell, it binds to it and is consequently transported into the cell in a vesicle. The cell will acidify the vesicle, causing human transferrin(TF) to release its iron ions. Each human transferrin molecule has the ability to carry two iron ions in the ferric form (Fe3+). Human Transferrin levels may be checked in iron deficiency, hemochromatosis and other iron overload disorders. Transferrin is also associated with the innate immune system. Human Transferrin is found in the mucosa and binds iron, thus creating an environment low in free iron, where few bacteria are able to survive. Source: Human plasma Synonyms: Transferin, TF, Apotransferrin, Beta-1 Metal-binding Globulin, DKFZp781D0156, PRO1400, PRO1557, PRO2086, Serotransferrin Precursor, Siderophilin CAS No: 11096-37-0 Molecular Weight: ~77kD Iron: ~0.12% Appearance: Supplied as a pink lyophilized powder. No stabilizing proteins added. Reconstitute lyophilized Transferrin in sterile ddH2O ≥100ug/ml, which can then be further diluted to other aqueous solutions. Purity: ~ 97% as determined by cellulose acetate Applications: Suitable for use in ELISA and affinity purification of anti-human transferrin antibodies. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Human Virus Test: FDA approved Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HBSAG, HBc, ALT and Syphilis. Viral inactivation by pasteurization (60°C for 10 hours) has been validated using three different test viruses, with removal of 8-14.5 logs of virus documented. The purification process has also been found to remove significant additional quantities of virus Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute by adding sterile ddH2O, aliquot and store at -20°C. Reconstituted product is stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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