Imugex

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Categories: Peptides & Proteins / Proteins

Product name			EIF2AK1, Recombinant, Human, GST-Tag (Eukaryotic Translation Initiation Factor 2-alpha kinase 1, HCR, HRI, KIAA1369)
Catalog No			USB-499943
Supplier’s Catalog No			499943
Supplier			US Biologicals
Source antigen			Recombinant, Insect cells
Reactivity
Cross reactivity
Applications
Molecular weight			120

Storage			-70°C
Other names
Grade			Purified
Purity			Purified (~70-90%)
Form			Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			Purified (~70-90%)
Description			EIF2AK1 (HRI) or eukaryotic translation initiation factor 2-alpha kinase 1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. EIF2AK1 (HRI) is a kinase that can be inactivated by hemin and is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-alpha. EIF2AK1 (HRI) is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. EIF2AK1 (HRI) functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia. Source: Recombinant protein corresponding to human EIF2AK1, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~120kD Specific Activity: 12nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.