Imugex

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Categories: Peptides & Proteins / Proteins

Product name			EIF2AK2, Recombinant, Human, GST-Tag (Double-Stranded RNA-Activated Protein Kinase, PKR, PRKR, EIF2AK1)
Catalog No			USB-499944
Supplier’s Catalog No			499944
Supplier			US Biologicals
Source antigen			Recombinant, Insect cells
Reactivity
Cross reactivity
Applications
Molecular weight			64

Storage			-70°C
Other names
Grade			Purified
Purity			Purified (~70-90%)
Form			Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			Purified (~70-90%)
Description			EIF2AK2 (also known as double-stranded RNA-activated protein kinase) is a protein kinase that has been shown to be involved in HIV/gp120-associated neurodegeneration. EIF2AK2 acts as a critical mediator of gp120 neurotoxicity and is a substrate for a family of protein kinases that respond to various forms of environmental stress. Activation of EIF2AK2 leads to its autophosphorylation and then phosphorylation of its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2. EIF2AK2 plays a critical role in mRNA translation, cell proliferation and apoptosis. A novel cross-talk between the EIF2AKs and p53 has been shown that has implications in cell proliferation and tumorigenesis. Source: Recombinant protein corresponding to human EIF2AK2, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~64kD Specific Activity: 53nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.