Tetradecanoyl Phorbol Acetate (TPA)
Catalog No : USB-T5600-03A
281.62€
0.00€
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| Product name | Tetradecanoyl Phorbol Acetate (TPA) | ||
|---|---|---|---|
| Catalog No | USB-T5600-03A | ||
| Supplier’s Catalog No | T5600-03A | ||
| Supplier | US Biologicals | ||
| Source antigen | |||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 616.83 | ||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ≥99% (HPLC) | ||
| Form | Supplied as a colorless film or foam (amorphous solid). | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ≥99% (HPLC) | ||
| Description | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Synonyms: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate CAS Number: 16561-29-8 Molecular Formula: C36H56O8 Molecular Weight: 616.80 Appearance: Supplied as a white to off-white solid. Purity: ≥99% (HPLC) Solubility: Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers. Storage and Stability: Powder may be stored at -20°C. Stable for 1 year after receipt at -20°C. Reconstitute with DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Protect from light. | ||
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