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Categories: Peptides & Proteins / Proteins

Product name			PTEN, Recombinant, Human (Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Dual-specificity Protein Phosphatase PTEN, Phosphatase and Tensin Homolog, Mutated in Multiple Advanced Cancers 1, PTEN, MMAC1, TEP1, BZS, MHAM, PTEN1, 10q23del)
Catalog No			USB-220209
Supplier’s Catalog No			220209
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			80

Storage			-70°C
Other names
Grade			Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a liquid. No preservative added.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Source: Recombinant protein corresponding to human PTEN, expressed in E. coli. Molecular Weight: ~80kD Biological Activity: A Phosphatase specific activity of ~400nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125mM in 20mM Tris, pH 7.5, 150mM NaCl, 50mM MgCl2, 0.05% Tween-20, 0.2% 2-mercaptoethanol. Endotoxin: <0.1ng/ug Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.