Imugex

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Categories: Peptides & Proteins / Proteins

Product name			TrkB-Fc Chimera, Human (Tropomyosin-Related Kinase Receptor, BDNF/NT-3 Growth Factors Receptor, Neurotrophic Tyrosine Kinase Receptor Type 2, TrkB Tyrosine Kinase, GP145-TrkB/GP95-TrkB, Trk-B, Ntrk2, Trkb, TrkB-Fc Chimera)
Catalog No			USB-215490
Supplier’s Catalog No			215490
Supplier			US Biologicals
Source antigen			Human 293 cells
Reactivity
Cross reactivity
Applications
Molecular weight			9011571

Storage			-20°C
Other names
Grade			Highly Purified
Purity			~95% (SDS-PAGE)
Form			Supplied as a lyophilized powder. Reconstitute with 500ul PBS.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (SDS-PAGE)
Description			Tyrosine Kinase Receptor B (TrkB) is a high affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. It also binds neurotrophin 3 (NT-3) with lower affinity. TrkB does not bind nerve growth factor (NGF). TrkB is involved in the development and/or maintenance of the nervous system and is widely expressed, predominantly in nervous tissue. TrkB is a heavily glycosylated type I transmembrane protein. The TrkB-Fc chimera contains 13 potential N-linked glycosylation sites. Source: TrkB-Fc Chimera, from human DNA sequence encoding the signal peptide and extracellular domain of human TrkB aa1-428 was fused to the Fc region of human IgG1 aa93-330. The chimeric protein was expressed in modified human 293 cells. Molecular Weight: ~90kD-115kD (SDS-PAGE) with post-transational modifications and ~71kD unmodified Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.