LYN B, Active, Recombinant, Human (Lyn B, V-yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, Lyn, Lck/Yes-related Novel Protein Tyrosine Kinase)
Catalog No : USB-220015
560.94€
0.00€
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| Product name | LYN B, Active, Recombinant, Human (Lyn B, V-yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, Lyn, Lck/Yes-related Novel Protein Tyrosine Kinase) | ||
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| Catalog No | USB-220015 | ||
| Supplier’s Catalog No | 220015 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Baculovirus (Sf9 insect cells) | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 85 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | Lyn is a 56kD tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck and the v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysis showed that a 3.2-kilobase Lyn mRNA was expressed in a variety of tissues of the human fetus. Lyn is expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that Lyn is physically associated with membrane-bound IgM, and participates in antigen-mediated signal transduction. Crosslinking of membrane-bound IgM with antibody induces rapid increase in activities of Lyn and Lyn-associated phosphatidylinositol 3-kinase. Crosslinking of B-cell antigen receptor also induces association of Lyn with an 85kD noncatalytic subunit of phosphatidylinositol 3-kinase. Thus, Lyn is functionally associated with membrane-bound IgM and participates in B-cell antigen receptor-mediated signaling. Source: Recombinant protein corresponding to active human LYN b, expressed in Baculovirus (Sf9 insect cells). Molecular Weight: ~85kD Biological Activity: ~180nmol phosphate incorporated into Poly(Glu-Tyr)/minute/mg protein at 30°C for 15 minutes using a final concentration of 50uM ATP (0.83uCi/assay). Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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