Imugex

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Categories: Peptides & Proteins / Proteins

Product name			MPZL1, Recombinant, Human, aa38-162, His-Tag (Myelin protein zero-like protein 1 Isoform b, MPZL1b, PZR, PZR1b, PZRa, PZRb)
Catalog No			USB-351373
Supplier’s Catalog No			351373
Supplier			US Biologicals
Source antigen			Recombinant, human from E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			16.1

Storage			-20°C/-70°C
Other names
Grade			Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.15M sodium chloride, 1mM DTT, 20% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			MPZL1 is a cell surface receptor, which is involved in signal transduction processes. This protein recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. It is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. Source: Recombinant protein corresponding to aa38-162 from human MPZL1, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~16.1kD (148aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSLEVYTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.