Imugex

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Categories: Peptides & Proteins / Proteins

Product name			c-MER, Recombinant, Human, GST-Tag (c-Mer Proto-oncogene Tyrosine Kinase, MER, MERTK, MGC133349)
Catalog No			USB-499833
Supplier’s Catalog No			499833
Supplier			US Biologicals
Source antigen			Recombinant, Insect cells
Reactivity
Cross reactivity
Applications
Molecular weight			58

Storage			-70°C
Other names
Grade			Purified
Purity			Purified (~70-90%)
Form			Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			Purified (~70-90%)
Description			c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family. The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product. Source: Recombinant protein corresponding to human c-MER, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~58kD Specific Activity: 1231nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.