FYN A, Recombinant, Human, GST-Tag (Fyn Isoform A, SLK, SYN, MGC45350)
Catalog No : USB-500026
572.43€
0.00€
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| Product name | FYN A, Recombinant, Human, GST-Tag (Fyn Isoform A, SLK, SYN, MGC45350) | ||
|---|---|---|---|
| Catalog No | USB-500026 | ||
| Supplier’s Catalog No | 500026 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Insect cells | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 85 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | Purified (~70-90%) | ||
| Form | Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified (~70-90%) | ||
| Description | Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2). The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML). Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib. Source: Recombinant protein corresponding to human FYN A, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~85kD Specific Activity: 166nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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