Imugex

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Categories: Peptides & Proteins / Proteins

Product name			ITK, Recombinant, Human, GST-Tag (352-end, EMT, LYK, PSCTK2, MGC126257, MGC126258)
Catalog No			USB-500187
Supplier’s Catalog No			500187
Supplier			US Biologicals
Source antigen			Recombinant, Insect cells
Reactivity
Cross reactivity
Applications
Molecular weight			53

Storage			-70°C
Other names
Grade			Purified
Purity			Purified (~70-90%)
Form			Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			Purified (~70-90%)
Description			ITK is a member of the TEC family of non-receptor tyrosine kinases. ITK is expressed in T-cells and is important for T-cell development and activation through the antigen receptor. ITK require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation and shares major substrates with both Lck and Zap-70. ITK knockout mice show multiple effects on T cell development, cytokine production and T-helper cell differentiation. T cells that lack or express mutant versions of ITK show impaired TCR-induced actin polymerization, cell polarization and regulation of the signaling events involved in cytoskeletal reorganization. Source: Recombinant protein corresponding to human ITK fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~53kD Specific Activity: 58nmol/min/mgas per activity assay protocol. Endotoxin: <1EU/ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.