SUMO1, Recombinant, Human (Small Ubiquitin-related Modifier 1, SUMO-1, GAP-modifying Protein 1, GMP1, SMT3 Homolog 3, Sentrin, Ubiquitin-homology Domain Protein PIC1, Ubiquitin-like Protein SMT3C, Smt3C, Ubiquitin-like Protein UBL1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43)
Catalog No : USB-S0750-01T
481.62€
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| Product name | SUMO1, Recombinant, Human (Small Ubiquitin-related Modifier 1, SUMO-1, GAP-modifying Protein 1, GMP1, SMT3 Homolog 3, Sentrin, Ubiquitin-homology Domain Protein PIC1, Ubiquitin-like Protein SMT3C, Smt3C, Ubiquitin-like Protein UBL1, SMT3C, SMT3H3, UBL1, OK/SW-cl.43) | ||
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| Catalog No | USB-S0750-01T | ||
| Supplier’s Catalog No | S0750-01T | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E.coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 11.7 | ||
| Storage | -20°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a lyophilized powder from 20mM Tris, pH 8, 10mM sodium chloride. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | The small ubiquitin-related modifier (SUMO) belongs to the growing family of ubiquitin-related proteins involved in posttranslational protein modification. It is present in all eukaryotic kingdoms and is highly conserved from yeast to humans. The SUMO family are composed of three types; SUMO1, SUMO2 and SUMO3. Like ubiquitin, SUMO1 is conjugated to target proteins by an enzymatic cascade involving E1, E2 enzyme and E3 lygase (known as sumoylation). It has been known that many substrates such as RanGAP1, PML and IkBa proteins are present in cells. In contrast to ubiquitination, sumoylation does not tag proteins for degradation by the 26S proteosome. Sumoylation participates in diverse events such as nuclear transport, transcriptional regulation, chromosome segregation and cell cycle control. Also the modification is associated with pathological conditions (neurodegeneration, diabetes and Inflammation). Source: Recombinant corresponding to aa1-97, with additional 3aa-GSH at N-terminal, from human SUMO1, expressed in E.coli. Molecular Weight: ~11.7kD Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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