FUBI, Recombinant, Human (Ubiquitin-like Protein Finkel-Biskis-Reilly Murine Sarcoma Virus, MNSF beta, 40S Ribosomal Protein S30, asr1, FAU, Fub1, RPS30, S30)
Catalog No : USB-145791
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| Product name | FUBI, Recombinant, Human (Ubiquitin-like Protein Finkel-Biskis-Reilly Murine Sarcoma Virus, MNSF beta, 40S Ribosomal Protein S30, asr1, FAU, Fub1, RPS30, S30) | ||
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| Catalog No | USB-145791 | ||
| Supplier’s Catalog No | 145791 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 7.8 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM HEPES, pH 8.0, 100mM NaCl, 1mM DTT. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | The Ubiquitin-like Protein Finkel-Biskis-Reilly Murine Sarcoma Virus (FUBI), also known as Monoclonal Nonspecific Suppressor Factor beta (MNSF beta), is a 74 amino acid (aa) Ubiquitin-like protein modifier with a predicted molecular weight of 8kD that is encoded by the FAU gene. FUBI/MNSF beta is translated as a fusion protein with the ribosomal protein S30; the fusion protein is post-translationally cleaved into two functional proteins. The mouse and rat FUBI/MNSF beta-ribosomal protein S30 fusion orthologs share 97% and 98% aa sequence identity with the human protein, respectively. Like many Ubiquitin-like proteins, FUBI/MNSF beta contains a C-terminal Gly-Gly motif and can be covalently conjugated to acceptor proteins to form adducts that modulate protein action. For example, FUBI/MNSF beta conjugation to Bcl-G inhibits the ERK1/ERK2 cascade downstream of TLR4 activation in macrophage cell lines. Additionally, FUBI/MNSF beta conjugation to Endophilin II has been shown to regulate Dectin-1-mediated phagocytosis and inflammation. The role of FUBI/MNSF beta downstream of TLR2 signaling is unclear, however novel FUBI/MNSF beta adducts may contribute to TLR2 signaling, as silencing of FUBI/ MNSF beta enhanced signaling via a TLR2-specific ligand. Source: Recombinant protein corresponding to human FUBI/MNSF beta. Molecular Weight: ~7.8kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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