UBE2W, Recombinant, Human, His-Tag (Ubc16, UBE2W Isoform 1)
Catalog No : USB-145854
580.48€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | UBE2W, Recombinant, Human, His-Tag (Ubc16, UBE2W Isoform 1) | ||
|---|---|---|---|
| Catalog No | USB-145854 | ||
| Supplier’s Catalog No | 145854 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 18.1 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS–PAGE) | ||
| Form | Supplied as a liquid in 50mM HEPES, pH 7.5, 200mM NaCl, 2mM DTT. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS–PAGE) | ||
| Description | Ubiquitin-conjugating Enzyme E2W (UBE2W), also known as Ubiquitin-conjugating Enzyme 16 (UBC16), is a member of the Ubiquitin-conjugating (E2) enzyme family. It has an E2 catalytic core domain with an active site cysteine residue that is required for the formation of a thioester bond with Ubiquitin. There are two isoforms of UBE2W, isoform 1 and isoform 2, with predicted molecular weights of 18.1kD and 19.5kD, respectively. UBE2W localizes to the nucleus where it promotes the mono-ubiquitination of BRCA1 and FANCD2, both of which contribute to DNA repair pathways. Mono-ubiquitination of the CHIP Ubiquitin ligase (E3), which has been reported to enhance its E3 ligase activity, is also mediated by UBE2W. Source: Recombinant protein corresponding to human UBE2W Isoform 1, fused to his-tag at N-terminal. Molecular Weight: ~18.1kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
Product Details
© 2020 Imugex All Rights Reserved