USP25, Recombinant, Human, His-Tag (Ubiquitin Thiolesterase 25, USP21)
Catalog No : USB-145857
591.97€
0.00€
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| Product name | USP25, Recombinant, Human, His-Tag (Ubiquitin Thiolesterase 25, USP21) | ||
|---|---|---|---|
| Catalog No | USB-145857 | ||
| Supplier’s Catalog No | 145857 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Spodoptera frugiperda, Sf 21 (baculovirus) | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 123 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM HEPES, pH 8.0, 200mM NaCl, 2mM DTT. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | USP25 (Ubiquitin Specific Protease 25) is a deubiquitinating enzyme of the C19 family that is expressed in many human tissue types. USP25 activity is modulated by a sumoylation event that is dependent on the presence of a SUMO-interaction domain (SIM) located in the amino-terminal region of all USP25 isoforms. Sumoylation occurs within one of two ubiquitin interaction motifs (UIMs) that are required for efficient in vitro hydrolysis of polyubiquitin chains (K48-linked or K63-linked) by USP25. While sumoylation impairs USP25 activity again polyubiquitin substrates, it does not affect its hydrolysis of ubiquitin-AMC. This protein contains a C-terminal 6-His tag. Source: Recombinant protein corresponding to human USP25, fused to 6-his tag at C-terminal. Molecular Weight: ~123kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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