Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Parkin, Human, Control Peptide (RING-type E3 ubiquitin-protein ligase)
Catalog No			USB-P3112-03A
Supplier’s Catalog No			P3112-03A
Supplier			US Biologicals
Source antigen			Human synthetic peptide
Reactivity			Human peptide sequence is conserved in alternatively spliced isoforms (isoform 1, 465 aa; isoforms 2, 437 aa; and isoform 3, 316 aa
Cross reactivity			Human,
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			Highly purified
Form			Supplied as a liquid in PBS, pH 7.2
Reactivity life			12 months
Note			For reserch purpose only
Purity			Highly purified
Description			A 23 amino acid peptide sequence mapping near the C-terminus of human parkin. Parkinson's is the second most common neurodegenerative disease after Alzheimer's. Parkinson's is characterized by movement disorders-triad of rigidity, resting tremor and bradykinesia. It has been attributed to loss of neurons that produce neurotransmitter dopamine. Recently a new gene, Parkin, has been identified by positional cloning (1) that is responsible for a rare autosomal recessive form of Parkinsonism, AR-JP (2). Human Parkin gene encodes a protein of 465aa (rat 465 aa; mouse 464 aa) with moderate similarity of ubiquitin at the N-terminus and RING-finger motif at the C-terminus. The gene has 12 exons, five of which (3-7) are deleted in AR-JP patients. Some other AR-JP patients have deletions affecting exon 4. Parkin is expressed in many tissues, including brain, heart, testis, and skeletal muscle. In the brain, parkin is expressed in various regions including substantia nigra. Parkin has recently been identified as an ubiquitin ligase (3). Applications: ELISA: 1:10K-1:100K using 50-100ng of control peptide/well.