C-Cbl, active, Recombinant, Human, GST-Tag (E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55)
Catalog No : USB-029430
790.83€
0.00€
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| Product name | C-Cbl, active, Recombinant, Human, GST-Tag (E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55) | ||
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| Catalog No | USB-029430 | ||
| Supplier’s Catalog No | 029430 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, Sf21 | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 127 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | ~75% (SDS-PAGE, Coomassie blue staining) | ||
| Form | Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 300mM sodium chloride, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | ~75% (SDS-PAGE, Coomassie blue staining) | ||
| Description | Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia. Source: Recombinant protein corresponding to full length human c-Cbl, fused to GST-tag at N-terminal, expressed by baculovirus in Sf21 insect cells Molecular Weight: ~127kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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