Imugex

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Categories: Peptides & Proteins / Proteins

Product name			MDM2, Active, Recombinant, Human, c-Myc GST-Tag (Ubiquitin-protein Ligase E3 Mdm2, p53-binding Protein Mdm2, Oncoprotein Mdm2, Double Minute 2 Protein, Hdm2)
Catalog No			USB-029535
Supplier’s Catalog No			029535
Supplier			US Biologicals
Source antigen			Recombinant, E.coli
Reactivity
Cross reactivity
Applications
Molecular weight			83

Storage			-70°C
Other names
Grade			Purified
Purity			~51% (SDS-PAGE, Coomassie blue staining)
Form			Supplied as a liquid in 50mM Tris/HCl, pH 7.5, 300mM sodium chloride, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			~51% (SDS-PAGE, Coomassie blue staining)
Description			MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours. Source: Recombinant corresponding to full length human MDM2, fused to GST at N-terminal c-Myc, expressed in E.coli. Molecular Weight: ~83kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.