Imugex

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Categories: Peptides & Proteins / Proteins

Product name			UBE2G1, Recombinant, Human, His-Tag (E217K, E2-17K, Ubiquitin-conjugating Enzyme E2G 1)
Catalog No			USB-145848
Supplier’s Catalog No			145848
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			20.3

Storage			-70°C
Other names
Grade			Highly Purified
Purity			~95% (SDS-PAGE)
Form			Supplied as a liquid in 50mM HEPES, pH 8.0, 150mM sodium chloride, 2mM DTT.
Reactivity life			6 months
Note			For reserch purpose only
Purity			~95% (SDS-PAGE)
Description			Ubiquitin-conjugating Enzyme E2G 1 (UBE2G1) is a 170 amino acid (aa) member of the Ubiquitin-conjugating (E2) enzyme family with a predicted molecular weight of 19.5kD. The human protein shares 100% aa sequence identity with the mouse and rat orthologs. UBE2G1 has an E2 catalytic core domain with an active site cysteine residue that is required for the formation of a thioester bond with Ubiquitin. The expression level of UBE2G1 is downregulated when miR-199a is overexpressed, suggesting that UBE2G1 mRNA is targeted by miR-199a. UBE2G1 has been reported to function with the CRL4(Cdt2) Ubiquitin ligase (E3) to promote the poly-ubiquitination and degradation of Cdt1. Reduced expression of UBE2G1 in medulloblastoma tumors has also been reported, suggesting that it may act as a tumor suppressor. Source: Recombinant protein corresponding to human UBE2G1, fused to 6-his tag at N-terminal. Molecular Weight: ~20.3kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.