Imugex

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Categories: Peptides & Proteins / Proteins

Product name			UBE2Q1 Isoform 2, Recombinant, Human, His-Tag (Ubiquitin-conjugating Enzyme E2 Q1, GTAP, NICE-5, PRO3094)
Catalog No			USB-145850
Supplier’s Catalog No			145850
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			29.3

Storage			-70°C
Other names
Grade			Highly Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a liquid in 50mM HEPES, pH 7.5, 200mM sodium chloride, 2mM DTT.
Reactivity life			6 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			Ubiquitin-conjugating Enzyme E2 Q1 (UBE2Q1) is a widely expressed, 422 amino acid (aa) member of the Ubiquitin-conjugating (E2) enzyme family with a predicted molecular weight of ~42.5kD. The human protein shares 99% aa sequence identity with the mouse and rat orthologs. UBE2Q1 has an RWD domain and an E2 catalytic core domain, the latter of which is required for the formation of a thioester bond with Ubiquitin. UBE2Q1 has been reported to regulate the internalization of the cell surface protein, GalT1. Female UBE2Q1-deficient mice produce litters with increased embryonic lethality and have decreased implantation capacity of homozygous mutant embryos, suggesting that UBE2Q1 is important for female fertility. Additionally, UBE2Q1 mRNA and protein expression levels are increased in breast cancer samples compared to non-cancerous breast tissue samples, suggesting that UBE2Q1 may play a role in cancer. Source: Recombinant protein corresponding to human UBE2Q1 Isoform 2, fused to 6-his tag at N-terminal. Molecular Weight: ~29.3kD Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.