Imugex

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Categories: Peptides & Proteins / Proteins

Product name			UbcH7, Recombinant, Human, His-Tag (Ubiquitin Conjugating Enzyme 7)
Catalog No			USB-209291
Supplier’s Catalog No			209291
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			18.9

Storage			-20°C
Other names
Grade			Highly Purified
Purity			~95% (RP-HPLC, SDS-PAGE)
Form			Supplied as a lyophilized powder in PBS, pH 7.5, 1mM DTT. Reconstitute with 100ug/ml sterile ddH2O.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (RP-HPLC, SDS-PAGE)
Description			Human Ubquitin Conjugating Enzyme 7 (UbcH7) is a class I enzyme which functions in the stress response and the control of transcription factors. The enzyme is ubiquitously expressed with high levels of expression seen in adult muscle. UbcH7 mediates the selective degradation of short-lived and abnormal proteins and is highly homologous to UbcH5. It has been demonstrated to participate in the ubiquitinylation of p53, c-Fos and NF-kB. UbcH7 is one of two E2s (UbcH5 being the other) with which HECT domain proteins interact with UbcH7 being able to efficiently substitute for UbcH5 in E6-AP-dependent ubiquitinylation. Source: Recombinant protein corresponding to 162aa from human UbcH7, fused to 6x His-tag, expressed in E. coli. Molecular Weight: ~18.9kD Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.