Imugex

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Categories: Peptides & Proteins / Proteins

Product name			Ubc13, Recombinant, Yeast, His-Tag (UBE2N, Ubiquitin-Conjugating Enzyme E2 N, Bendless-like Ubiquitin-Conjugating Enzyme, Ubiquitin Carrier Protein N, Ubiquitin-Protein Ligase N, BLU, MGC8489, UbcH-ben, MGC131857)
Catalog No			USB-220368
Supplier’s Catalog No			220368
Supplier			US Biologicals
Source antigen			Recombinant, Saccharomyces cerevisiae
Reactivity
Cross reactivity
Applications
Molecular weight			18.46

Storage			-70°C
Other names
Grade			Highly Purified
Purity			~95% (SDS-PAGE)
Form			Supplied as a liquid in 50mM HEPES, pH 7.5, 150mM sodium chloride, 10% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~95% (SDS-PAGE)
Description			Ubc13 is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Ubc13 acts with the UEV protein Mms2 forming a heterodimeric complex that assembles K63-linked polyubiquitin chains utilized in nondegradative ubiquitin signaling pathways (DNA repair, signal transduction). The Ubc13/Mms2 complex is unique in that it has the ability to form free K63-linked polyubiquitin chains in solution in the absence of an E3. UBE2N mediates the transcription of some target genes and is believed to have a role in cell cycle progression; cellular differentiation and DNA repair mechanisms which ensure cell survival after DNA damage. Source: Recombinant protein corresponding to yeast Ubc13, fused to His-tag, expressed in Saccharomyces cerevisiae. Molecular Weight: ~18.46kD with His Tag Biological Activity: Typical enzyme concentration of 100nM-5mM is used for in vitro conjugation, depending on conditions. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.