UbcH1, Recombinant, Human (UBE2K, HIP2, Huntingtin Interacting Protein 2, HYPG, Ubiquitin-Conjugating enzyme E2-25KkD, Ubiquitin-Protein Ligase, Ubiquitin Carrier Protein, LIG, HIP-2, E2 (25K), DKFZp686J24237, EC 6.3.2.19)
Catalog No : USB-220369
577.03€
0.00€
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| Product name | UbcH1, Recombinant, Human (UBE2K, HIP2, Huntingtin Interacting Protein 2, HYPG, Ubiquitin-Conjugating enzyme E2-25KkD, Ubiquitin-Protein Ligase, Ubiquitin Carrier Protein, LIG, HIP-2, E2 (25K), DKFZp686J24237, EC 6.3.2.19) | ||
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| Catalog No | USB-220369 | ||
| Supplier’s Catalog No | 220369 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 22.41 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (RP-HPLC) | ||
| Form | Supplied as a liquid in TBS. No preservative added. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (RP-HPLC) | ||
| Description | UBE2K, also known as UbcH1 or E2-25K, is an E2 (ubiquitin conjugating enzyme) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E3 enzymes. Once an E1 is carrying an activated ubiquitin in a ubiquitin-E1 thiolester complex, this activated ubiquitin is transferred to the active site cysteine of the E2 to form a ubiquitin-E2 thiolester complex. With the aid of an E3, the activated ubiquitin is then targeted to a specific substrate lysine. UBE2K is a biochemically important E2 due to its ability to form free K48-linked polyubiquitin chains in solution in the absence of an E3. This ability is attributed to UbcH1 possessing a C-terminal UBA domain, in addition to its E2 catalytic domain. UBE2K takes part in many cellular processes such as selective protein degradation, DNA repair, cell cycle control, and sporulation. In addition, UBE2K is involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with amyloid-beta, Huntington, and MHC-heavy chain proteins. Source: Recombinant protein corresponding to human UBE2K. Molecular Weight: ~22.41kD Biological Activity: Typical enzyme concentration of 100nM-1mM is used for in vitro conjugation, depending on conditions. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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