Plasminogen Activator Inhibitor Type 1, mutant, minimal vitronectin binding (PAI-1)
Catalog No : USB-P4256-29M
1133.37€
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| Product name | Plasminogen Activator Inhibitor Type 1, mutant, minimal vitronectin binding (PAI-1) | ||
|---|---|---|---|
| Catalog No | USB-P4256-29M | ||
| Supplier’s Catalog No | P4256-29M | ||
| Supplier | US Biologicals | ||
| Source antigen | |||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 43 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | |||
| Form | |||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | |||
| Description | Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6). Physical Appearance: Colorless frozen solution Solubility: >2mg/ml and <5mg/ml Buffer Composition: 0.05M sodium phosphate; 0.1M sodium chloride; 1mM EDTA; pH 6.6. Purity: >98% pure by SDS PAGE 95 (+/-) 5% active by uPA titration. Absorbance (280nm): 1.84 E0.1% = 1.0 Concentration = 1.84mg/ml Active Concentration = 1.8mg/ml Kinetic Data: Second order rate constants for inhibition of: UPA = 6.3 X 106 M^-1s^-1 tPA = 5.7 X 106 M^-1s^-1 Storage and Stability: Store frozen at -70°C – stability >1 year | ||
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