Recombinant Human IL15
Catalog No : IGX-RP413
4512.77€
0.00€
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| Product name | Recombinant Human IL15 | ||
|---|---|---|---|
| Catalog No | IGX-RP413 | ||
| Supplier’s Catalog No | IGX-RP413 | ||
| Supplier | ImuGeX | ||
| Source antigen | E. coli | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 13 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | IL-15, IL-T<br/>Recombinant Human Interleukin-15 (IL15) | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Recombinant IL-15 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | IL-15 has been shown to be produced by human fetal astrocytes and microglial cells in response to IL-1-beta, IFN-gamma, or TNF-alpha and may thus play a role in T cell mediated immune responses in the human central nervous system. IL-15 stimulates proliferation of the established T cell line CTLL-2, CD8(+) memory T cells require IL-15 for proliferation. IL-15 is also able to induce generation of cytolytic cells and LAK cells activity in vitro. IL-15 appears to function as a specific maturation factor for natural killer cells and can mimic the bone marrow microenvironment in vitro, which is required for natural killer cells to acquire lytic functions. IL-15 induces proliferation of mast cells in the absence of functional IL-2 receptor components and utilizes a receptor of 60-65 kDa that is distinct from known components of T cell IL-15 receptors. The IL-15 receptor on mast cells recruits JAK2 and STAT5, instead of JAK1, JAK3 and STAT3 and STAT5 that are activated in T cells. The alpha subunit of the IL-15 receptor (IL-15RA) is structurally related to the alpha subunit of the IL-2 receptor and confers high affinity binding of IL-15 to its receptor. IL-15 binds to the beta and gamma chains of the IL-2 receptor, which are known to be required for ligand internalization and signal transduction. | ||
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