Recombinant Rat IL5
Catalog No : IGX-RP449
6019.02€
0.00€
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| Product name | Recombinant Rat IL5 | ||
|---|---|---|---|
| Catalog No | IGX-RP449 | ||
| Supplier’s Catalog No | IGX-RP449 | ||
| Supplier | ImuGeX | ||
| Source antigen | E. coli | ||
| Reactivity | Rat | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 13 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | IL-5, B cell growth factor II, BCGF-II, Cytotoxic T lymphocyte inducer, Eosinophil differentiation factor T cell replacing factor, TRF <br/>Recombinant Rat Interleukin-5 (IL5) | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Recombinant rat Interleukin-5 was lyophilized from a 0.2 μm filtered PBS solution. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | Interleukin-5 is a specific hematopoietic growth factor that is responsible for the growth and differentiation of eosinophils. IL-5 promotes the growth of immature hematopoietic progenitor cells BFU-E while it causes differentiation of CFU-E the proliferation of which is inhibited by IL-5. IL-5 strongly stimulates the proliferation, cell activation, and differentiation of eosinophils. B cells can be made responsive to IL-5 by treatment with suboptimal doses of IL-1. Interleukin-5 also promotes the generation of cytotoxic T cells from thymocytes. In thymocytes IL-5 induces the expression of high affinity IL-2 receptors. In contrast to human Interleukin-5, mouse IL-5 also acts on B cells. It induces the proliferation of pre-activated B cells and their differentiation. High affinity and low affinity receptors for IL-5 are expressed in all hematopoietic and lymphoid cells.The low affinity receptor, CD125, has a molecular mass of 50 kDa (p60). The introduction of p60 into these cells generates a high affinity IL-5 receptor. The second subunit of the IL-5 receptor is identical with the larger subunit of the receptor for the colony stimulating factor GM-CSF (CD131). This subunit is involved also in the generation of a high affinity receptor for IL-3 and is being referred to as common beta. | ||
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