Recombinant Human Noggin (NOG)
Catalog No : IGX-RP452
4299.38€
0.00€
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| Product name | Recombinant Human Noggin (NOG) | ||
|---|---|---|---|
| Catalog No | IGX-RP452 | ||
| Supplier’s Catalog No | IGX-RP452 | ||
| Supplier | ImuGeX | ||
| Source antigen | E. coli | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 23 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | NOG | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Human Noggin was lyophilized from a 0.2 μm filtered solution in PBS, pH 7. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | Noggin is a secreted homodimeric glycoprotein that binds to ligands of the TGF-beta family (BMPs) and regulates their activity by inhibiting their access to signaling receptors. Mature human Noggin protein contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine knot structure. Noggin binds different BMPs with variable affinities, antagonizing specific BMPs during skeletal development. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. | ||
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