Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, Ctla8, Il17<br/>Recombinant Mouse Interleukin-17 (IL17)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Lyophilized from a 0.2 μm filtered solution in PBS
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			Interleukin-17 (IL-17 or IL-17A) is the founder member of the IL-17 cytokine family, which shares 50% homology with IL-17F. IL-17 cytokines are produced by T helper (TH)17 cells, gamma delta T cells, and other immune cells. IL-17A and IL-17F form homodimers and heterodimers as functional ligands. IL-17 cytokines bind to two receptors, IL-17RA and IL-17RC. IL-17RC forms a receptor heterodimer with IL-17RA. The receptor heterodimer is preferred by IL-17 ligands, thus, either IL-17RA knockout (KO) or IL-17RC KO completely abolishes IL-17 signaling. IL-17A and IL-17F are key proinflammatory cytokines involved in many inflammatory and autoimmune diseases.