Recombinant Human FGF23
Catalog No : IGX-RP475
4512.77€
0.00€
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| Product name | Recombinant Human FGF23 | ||
|---|---|---|---|
| Catalog No | IGX-RP475 | ||
| Supplier’s Catalog No | IGX-RP475 | ||
| Supplier | ImuGeX | ||
| Source antigen | E. coli | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 23 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, HYPF<br/>Recombinant Human Fibroblast Growth Factor 23 (FGF23) | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Recombinant Human FGF23 was lyophilized from 0.2 μm filtered PBS solution, pH 7.4. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | FGF-23 is a protein of ∼30 kDa that is proteolytically processed to generate smaller N-terminal (18 kDa) and C-terminal (12 kDa) fragments. The N-terminal fragment of FGF-23 contains the FGF receptor (FGFR)-binding domain. In vivo studies using synthetic peptides have indicated that neither of the processed N-terminal or C-terminal fragments of FGF-23 can influence serum phosphate levels. FGF-23 can decrease the activity of NaPi-2a and NaPi-2c cotransporters to reduce renal phosphate reabsorption and thereby can increase urinary phosphate excretion. Similarly, FGF-23 can suppress the expression of 1-alpha-hydroxylase to reduce the production of the active vitamin D metabolite 1,25(OH)2D. Moreover, FGF-23 can also induce 24- hydroxylase, which degrades 1,25(OH)2D | ||
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