Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			Cytokine Zcyto20, Interleukin-28A, Interferon lambda-2
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Lyophilized from a 0.2 µm filtered solution in PBS (with BSA as a carrier protein)
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			Interferon lambda-2, also known as Interleukin 28A, is an antiviral cytokine with immunomodulatory activity and is distantly related to the IL-10 family and type I interferons. IL28A along with IL29 and IL28B, are three closely related cytokines that form a cytokine gene cluster that use a distinct receptor system which induces antiviral defence signals. IL28A interacts with a heterodimeric class II cytokine receptor ligand and leads to the activation of the JAK/STAT signalling pathway, which ultimately leads to IFN-stimulated gene (ISG) and MHC class I antigen expression. It also plays a key role in antiviral defence in Toll-like receptors (TLR) and intestinal epithelia.