Recombinant Human Persephin (PSPN)
Catalog No : IGX-RP563
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| Product name | Recombinant Human Persephin (PSPN) | ||
|---|---|---|---|
| Catalog No | IGX-RP563 | ||
| Supplier’s Catalog No | IGX-RP563 | ||
| Supplier | ImuGeX | ||
| Source antigen | E. coli | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 10.7 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | PSP | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA (with BSA as a carrier protein) | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | Persephin is a disulfide-linked homodimeric neurotrophic factor belonging to the Transforming Growth Factor-beta (TGF-beta) superfamily and the GDNF sub-family. One cysteine residue, out of the seven conserved, is used for inter-chain disulfide bridging while the others form a cysteine knot ring formation. It signals through RET and one of the four GFR-alpha (alpha-1, alpha-2, alpha-3, alpha-4) receptors to promote the proper development and maintenance of the nervous system. Persephin promotes survival of dopaminergic neurons in the midbrain as well as some motor neurons, and promotes branching of ureteric buds. | ||
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