Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			TNF-alpha, Cachectin, Tumor necrosis factor ligand superfamily member 2, TNF-a, Tnfa, Tnfsf2, Tumor necrosis factor <br/>Recombinant Rat Tumor Necrosis Factor Alpha (TNF)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Lyophilized from a 0.2 μm filtered PBS solution (pH 7.0)
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			TNF is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17 kDa and a length of 157 amino acids. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers.