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Categories: Peptides & Proteins / Proteins

Product name			Recombinant Human CXCL12 (SDF-1 alpha)
Catalog No			IGX-RP591
Supplier’s Catalog No			IGX-RP591
Supplier			ImuGeX
Source antigen			E. coli
Reactivity			Human
Cross reactivity
Applications
Molecular weight			8

Storage			-70°C
Other names			Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH, Pre-B cell growth-stimulating factor, PBSF<br/>Recombinant Human Stromal Cell-Derived Factor-1 Alpha (CXCL12)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			SDF-1-alpha and SDF-1-beta are small cytokines belonging to the CXC-Chemokines. SDF-1 is identical with a chemokine reported to function as a pre-B-cell growth factor in the presence of IL-7 and isolated originally from a murine bone marrow stromal cell line. Human SDF-1-alpha and SDF-1-beta are encoded by a single gene and arise by alternative splicing. SDF-1 acts on lymphocytes and monocytes but not neutrophils in vitro and is a highly potent chemoattractant for mononuclear cells in vivo. In addition. SDF-1 also induces intracellular actin polymerization in lymphocytes. SDF acts as a chemoattractant for human hematopoietic progenitor cells expressing CD34 giving rise to mixed types of progenitors, and more primitive types. The chemotactic response is inhibited by pertussis toxin. Chemotaxis of CD34(+) cells in response to SDF is increased by IL-3 in vitro. SDF has been shown also to induce a transient elevation of cytoplasmic calcium in these cells.