Recombinant Mouse IL13
Catalog No : IGX-RP662
412.43€
0.00€
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| Product name | Recombinant Mouse IL13 | ||
|---|---|---|---|
| Catalog No | IGX-RP662 | ||
| Supplier’s Catalog No | IGX-RP662 | ||
| Supplier | ImuGeX | ||
| Source antigen | E. coli | ||
| Reactivity | Mouse | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 12 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | IL-13, T-cell activation protein P600<br/>Recombinant Mouse Interleukin-13 (IL13) | ||
| Grade | Highly Purified | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Form | Recombinant mouse IL-13 was lyophilized from a 0.2 μm filtered PBS solution. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | >95% as determined by SDS-PAGE | ||
| Description | Mouse IL-13 is produced primarily by activated Th2 cells. Human IL-13 is expressed in activated T helper cells (resembling Th0, Th1, Th2), and T cells expressing CD8. The alpha chain of the IL-13 receptor has weak binding activity for IL-13. High affinity receptors are formed when the receptor alpha chains of IL-13 and IL-4 receptors are coexpressed. The receptors for IL-13 and IL-4 share a component, a common gamma subunit that is found also in the IL-2 receptor. Different IL-13 receptor structures have been shown to exist on various cell types and the IL-13 receptor may share more than one component with IL-4 receptor. IL-13 down-modulates macrophage activity, reducing the production of pro-inflammatory cytokines and chemokines in response to IFN-gamma or bacterial lypopolysaccharides. IL-13 enhances the production of the IL-1 receptor antagonist IL-1ra. IL-13 also decreases the production of nitric oxide by activated macrophages, leading to a decrease in parasiticidal activity. IL-13 induces differentiation of human monocytes, enhances survival time in culture, and also induces differentiation and proliferation and isotype switching in B cells. | ||
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