Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			IL-33<br/>Recombinant Mouse Interleukin-33 (IL33)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant Interleukin-33 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5._x000D_ _x000D_
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			IL-33, a member of the IL-1 family, signals via a heterodimeric receptor complex consisting of ST2 and IL-1R accessory protein and triggers the activation of NF-B and all three MAPKs: p38, ERK1/2, and JNK1/2 in mast cells. IL-33 is expressed in multiple tissues and by several cell types such as dermal fibroblasts and small airway epithelial and bronchial smooth muscle cells. IL-33 activated IL-1-like signaling responses in mast cells and enhanced IL-5 and IL-13 production from murine Th2-polarized splenocytes. Moreover, it was found that both human and murine mast cells when stimulated in vitro with IL-33 produced a wide spectrum of cytokines and chemokines . In addition, IL-33 enhanced IL-4-driven Th2 cell responses and acted as a selective chemoattractant for Th2 cell recruitment._x000D_