Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			Somatomedin, Insulin-like growth factor I, IGF-I, Igf1<br/>Recombinant Rat Insulin-Like Growth Factor (IGF1)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			Recombinant Rat IGF1 was lyophilized from a 0.2 μm filtered PBS solution, pH 7.4.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-I is synthesized as two precursor isoforms with N- and alternate C- terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C- terminal regions. Mature human IGF-I shares 94% and 96% aa sequence identity with mouse and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF-II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects.