Recombinant Human BUB1B (N-GST tag)
Catalog No : IGX-RP742
366.40€
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| Product name | Recombinant Human BUB1B (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP742 | ||
| Supplier’s Catalog No | IGX-RP742 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 73 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | SSK1, BUBR1, Bub1A, MAD3L, hBUBR1, BUB1beta | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | BUB1B or budding uninhibited by benzimidazoles 1 homolog beta is involved in spindle checkpoint function and has been localized to the kinetochore. BUB1B plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation . BUB1B links the regulation of chromosome-spindle attachment to mitotic checkpoint signaling . BUB1B expression during the spindle checkpoint is dependent on residual BUB1B expression and impaired spindle checkpoint function has been found in many forms of cancer. BUB1B is essential for early embryonic development and normal hematopoiesis. | ||
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