Recombinant Human c-MER (N-GST tag)
Catalog No : IGX-RP744
366.40€
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| Product name | Recombinant Human c-MER (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP744 | ||
| Supplier’s Catalog No | IGX-RP744 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 58 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | MER, MERTK, MGC133349 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family . The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product . | ||
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