Recombinant Human CHK2 (N-GST tag)
Catalog No : IGX-RP779
366.40€
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| Product name | Recombinant Human CHK2 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP779 | ||
| Supplier’s Catalog No | IGX-RP779 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 88 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | RP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner . Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization . | ||
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