Recombinant Human DAPK2 (N-GST tag)
Catalog No : IGX-RP797
366.40€
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| Product name | Recombinant Human DAPK2 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP797 | ||
| Supplier’s Catalog No | IGX-RP797 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 67 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | DRP-1; MGC119312 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | DAPK2 or death-associated protein kinase 2 belongs to a family of proapoptotic Ca(2+)/calmodulin-regulated serine/threonine kinases. Overexpression of DAPK2 induces cell apoptosis. DAPK2 has been shown to be a novel Sp1-dependent target gene for E2F1 and Krüppel-like factor 6 (KLF6) in cell death response . Both E2F1 and KLF6 strongly activate the DAPK2 promoter. DAPK2 plays a role in granulopoiesis where it is highly expressed. ß-catenin can block anoikis of malignant kidney and intestinal epithelial cells and promote their anchorage-independent growth by down-regulating DAPK2 . ß-catenin-induced down-regulation of DAPK2 requires the presence of the transcription factor TCF-4. | ||
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