Recombinant Human DYRK4 (N-GST tag)

Catalog No : IGX-RP809
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Product name Recombinant Human DYRK4 (N-GST tag)
Catalog No IGX-RP809
Supplier’s Catalog No IGX-RP809
Supplier ImuGeX
Source antigen Insect cells
Reactivity Human
Cross reactivity
Applications
Molecular weight 90
Storage -70°C
Other names None
Grade Highly Purified
Purity 70% - 90%
Form 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Reactivity life 6 months
Note For reserch purpose only
Purity 70% - 90%
Description DYRK4 or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 plays an important role in cell proliferation, survival, and development . Northern blot analysis shows DYRK4 is highly expressed in the testis with a very restricted expression to stage VIII postmeiotic spermatids . Analysis of a DYRK4 deficient mouse line showed that DYRK4 is dispensable for male fertility, hence suggesting a functional redundancy of some DYRK isoforms during spermiogenesis. DYRK4 protein contains a DYRK homology box in its N-terminal half, followed by a central kinase domain with a YxY loop.