Recombinant Human EIF2AK3 (N-GST tag)
Catalog No : IGX-RP814
366.40€
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| Product name | Recombinant Human EIF2AK3 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP814 | ||
| Supplier’s Catalog No | IGX-RP814 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 115 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | PERK, PEK, WRS, HRI, DKFZp781H1925 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation and a rapid reduction of translational initiation and repression of global protein synthesis. EIF2AK3 is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins . EIF2AK3 plays a major role in the ability of cells to adapt to ER stress and is also involved in an integrated adaptive response to hypoxic stress in HeLa cells . EIF2AK3 functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia. | ||
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