Recombinant Human FLT3 (N-GST tag)
Catalog No : IGX-RP844
366.40€
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| Product name | Recombinant Human FLT3 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP844 | ||
| Supplier’s Catalog No | IGX-RP844 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 73 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | FLK2, STK1, CD135 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | FLT3 is a receptor tyrosine kinase that has been shown to play a role in proliferation and survival of hematopoietic progenitor cells as well as differentiation of early B lymphoid progenitors . FLT3 consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML). About 30 to 35% of patients have either internal tandem duplications (ITDs) in the juxtamembrane domain or mutations in the activating loop of FLT3 . The consequence of either FLT3-ITD or activating loop mutations is the constitutive activation of the tyrosine kinase activity. | ||
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