Recombinant Human FYN A (N-GST tag)
Catalog No : IGX-RP848
366.40€
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| Product name | Recombinant Human FYN A (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP848 | ||
| Supplier’s Catalog No | IGX-RP848 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 85 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | SLK, SYN, MGC45350 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2) . The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML) . Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib. | ||
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