Recombinant Human GRK2 (N-GST tag)
Catalog No : IGX-RP852
366.40€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Recombinant Human GRK2 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP852 | ||
| Supplier’s Catalog No | IGX-RP852 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 102 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | ADRBK1; BARK1; BETA-ARK1, FLJ16718 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | GRK2 or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart . RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2 . After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity. | ||
Product Details
© 2020 Imugex All Rights Reserved