Recombinant Human IKK alpha (N-GST tag)
Catalog No : IGX-RP873
366.40€
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| Product name | Recombinant Human IKK alpha (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP873 | ||
| Supplier’s Catalog No | IGX-RP873 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 114 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | CHUK, IKK1, IKBKA, TCF16, NFKBIKA, IKK-alpha | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | IKKa is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex . IKKa is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure . IKKa is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFNa production. IKKa is also involved in the epidermis where it antagonizes mitogenic and angiogenic signals and represses tumor progression and metastases. | ||
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