Recombinant Human IKK beta (N-GST tag)
Catalog No : IGX-RP874
366.40€
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| Product name | Recombinant Human IKK beta (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP874 | ||
| Supplier’s Catalog No | IGX-RP874 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 105 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | IKK2, IKBKB, IKKB, NFKBIKB, FLJ40509, IKK-beta, MGC131801 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | IKKß is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKKß is stimulated by TNF and IL1 and IKKß forms a heterodimer that interacts with NIK . Overexpression of catalytically inactive IKKß blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKKß activity in vitro and in vivo by binding to IKKß to reduce ATP binding . | ||
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