Recombinant Human NIK (N-GST tag)
Catalog No : IGX-RP954
366.40€
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| Product name | Recombinant Human NIK (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP954 | ||
| Supplier’s Catalog No | IGX-RP954 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 108 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | MAP3K14, HS, HSNIK, FTDCR1B | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | NIK is a mitogen-activated protein kinase kinase kinase 14 (MAP3K14), which binds to TRAF2 and stimulates NF-kappaB activity. NIK shares sequence similarity with several other MAPKK kinases and participates in NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. NIK is expressed in primary human cells and in inflamed rheumatoid arthritis tissue and plays a selective role in signaling by the lymphotoxin-beta receptor . NIK is a therapeutic target in the immune and bone-destructive components of inflammatory arthritis. | ||
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